Protein Details: Aquaporin-12A

Protein ID

ICDB_Pro_1256

Protein Name

Aquaporin-12A

Gene Name

AQP12A; AQP12; AQPX2

Organism

Homo sapiens (Human)

Length

295 amino acids

AlphaFoldDB

AF-Q8IXF9-F1-model_v4.pdb

Function

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.

Sequence

MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSGVEGPHSS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Primary Hyperoxaluria and Keratomalacia

Location

Restricted to the pancreas

DOI ID

10.1016/j.bbrc.2005.03.046

RefSeq

NP_945349.1